Note:In this scenario are you asking which abilties would we rather have in narutoverse or in the real world.
well, lets look at their core abilities:
Tsunade-Healing/super strength
Jiriaya-Sage Mode with assistance/variety of ninjustu/good at fuinjustu
Orochimaru-Oral Birth Regeneration ( atleast healing on par with Tsunade Mitotic regen)/psuedo immortality (body switch)/ and a few ninjustu (snake hands, wind breakthrough etc.)-Snake transformation
So, considering their powers I think the decision becomes obvious. Orochimaru seems to have the most usefull powers.
If we are talking about real world scenario then I think I would choose Orochimaru, then tsunade, then jiriaya. Because, psuedo-immortality is usefull in this world and the naruto one. I would pick Tsunade over jiraiya because I would make a fortune with her healing abilties. Though, jirayas invisiblity just would be fun lol.
In the narutoverse setting, I would still chose Orochimaru's powers because between oral rebirths regeneration, body switching, and curse seal reincanation aslong as i am carefull ( which I usually am ) I don't see me dieing any time soon- which is always a good thing. THen I would chose Jiriaya, because with my toad allies backing me up, providing sage mode- I would be a tank, defending my freinds and crushing enemies. Tsunade would be last because, while her healing is great, If I had Sage Mode I doubt I would need a medic very often, and with orochimaru's powers I won't need Tsunades healing eithor. Now super strength is very powerfull, but personally I would much rather fight from a distance than close up.
Seriously, it's kinda strange how the Sanin who has yet to go all out-at max power ( so he has abilties yet to be shown) appeals to me so much more than the other two sannin. . --