Which other fictional characters are similar to Orochimaru's characters from other genres?

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Dio Brando is an antagonist from JoJo’s Bizarre Adventure.

Hisoka is an antagonist from Hunter x Hunter
Mayuri from bleach. Both are immortal crazy scientist however mayuri doesn't seek perfection and explained why true scientist would never.
Thanks.
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Mr. Sinister is the closest to Orochimaru in the Marvel universe.
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I think Brainiac or Lex Luthor or Joker from DC.
 
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