Using only canon (manga) info, I believe that -outside Naruto- Lee has the greatest, and a very real chance- at defeating Sasuke, and I'll give my reasons (which means I expect REAL rebuttal from the Sasuke defenders, an not just fanboying).
Lee proved in their first encounter that he was a superior Taijutsu fighter than Sasuke, and it serves to reason that this fact is maintained, as Lee trains religiously in close combat, while Sasuke is very Ninjutsu focused. Going off of this fact, we know well that it's not always possible for an Uchiha's body to keep up with their eyes. Lee is already known as one of the fastest characters in the continuity. And he'll get stronger and faster without opening the Gates...
Lee takes off his weights, and I'm willing to bet this makes it nearly impossible for un-EMS Sasuke to keep up. And since F=MV, as Lee's speed increases, so does the force behind his blows.
Then we have the Eight Gates, which makes one exponentially stronger; at Six Gates, Sasuke can't track Lee anymore (with Weights removed), even with EMS. Lee's powerful enough at this point to break through Sasuke's Susanno'o (up to how far we've seen him use it.)
All Lee has to do now is break through and finish the job.
And this is all assuming he has no alcohol on him.
Now, for a few discrepancies: Lee CAN open all Eight Gates - anyone with training can - but does not due to his training - if he continues to open all the Gates, Sasuke ha no chance at even tracking him, and Susanno'o shatters from the force of he blows.
Wrapping Susanno'o in Amaterasu doesn't make Sasuke invincible. Amaterasu burns slowly, meaning Lee still has time to kill Sasuke if he decides to barrel through a Blaze Release'd Susanno'o.
Since Sasuke lacks serious Genjutsu skills, Lee simply avoids eye-contact, and the Genjutsu deilama is no more.
And you are just a troll :sy:all of you are sasuke fan boy!!! any of the 11 can beat him!!! hands down...
Sasuke Smart but to hot headed so that's. His down fall trust me neji gone losses to sasukes power lee gets him in 8 gates but susanoo can be destroyed by some gates move and over all sasuke kills all
I notice alot of people keep saying rock lee in 8 gates. But how? The ONLY thing that Rock Lee can do in 8 gates against Sasuke is dodge Amaterasu and attacks from Susanoo effectively. And not to mention that 8 gates doesn't necessarily last long, and afterwards Lee would be exhausted and would be left completely vulnerable.
Shikamaru would stay alive the longest but Sasuke wouldn't sweat a bit and Rock Lee w/ 8 Gates will make Sasuke sweat a little bit.
For Neji, I doubt it.. I think Shino and Sai stands a better chance than Neji does. Sasuke can just spam Amaterasu arrows at Neji constantly till he stops the rotation, I doubt Neji could rotate as long as Sasuke could keep shooting his arrows (chakra-wise).
I'll say this from the best chance to the least in this order:
Rock Lee
Shikamaru
Shino
Sai
Neji
Sakura
Choji
Hinata
Tenten
Kiba
Ino
You actually think Neji stands a chance, unbelievable. Sasuke destroys them all.