What would it take to permanently kill Orochimaru ?

[Lord Tywin]

he said something like a bijuu bomb by four tails naruto would do the trick. Killing his horcroxes would end him permanently

 

[Joker]

Orochimaru is dead. Sealed forever in the Totsuka dream world. He just has a shell of his consciousness floating around the world now.

It's the same as if I genetically formed a clone of myself with all my memories and then killed myself. I'm still dead.

Bring sealed doesn't equate to being dead, so no. Regardless, it's Orochimaru.

 

[DannySenju]

kill all the people with curse marks. Including Anko. Then seal him with Death Reaper.

this is how he will be killed.

 

[LuckyMan]

He said a Tailed Beast Ball can kill him. But he could eventually revive out of anyone who has a curse seal when they get low on chakra or want to release him.

 

[slaton02]

One Great Shark Bullet

 

[Your Creepy Stalker]

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[Tenasa Uchiha]

Man who know maybe an atomic bomb

 

[Jessika Uzumaki]

Let him listen to Justin Beiber, that should kill him FOR GOOD!!!!