The way anime is going, very little of it is going to be hand drawn -- almost all of it done by computer graphics. Manga, of course, will stay the same, as long as there's a market for it (there is).
The direction anime goes depends on how well-funded and trained the development team is. Underfunded, we get animation like Madara versus Potato Jesus. Well-funded with good developers, we get "the boulder that flies into the church bell in Attack on Titan".
In short: it's going to be the exact same thing give or take technological advancements (but that didn't stop 70s anime from being vibrant as hell!).