Hashirama comes out of Madara's chest. That would be a hell of a twist, but would also be interesting. Orochimaru was sealed and came back, why not Hashirama? xd
If Madara becomes the Juubi Host... and then realizes he's had a curse mark on his neck the whole time. Orochimaru takes over his body and becomes the Juubi Jinchurriki.
Sasuke + Naruto + Sakura (yes, her) VS Edo Orochimaru Juubi Jinchurriki
If in the end, after all of us here at the amazing NarutoBase started this whole Ramen Guy fanbase, the ramen guy turns out to be the main villian of Naruto and the Juubi host. I wouldn't be surprised.