i could see it happening. i wouldnt be surprised at all since Tsunade's super strength was able to punch through susano, then that could have foreshadowed a possible outcome if Sakura got a chance to hit Sasuke. She already has got it in her mind that he should be dealt with so hopefully if this does happen and she gets another chance to fight him she shouldnt let her emotions stall her.
And itd be freaking amazing to see Sasuke get defeated by Sakura...after this last manga with Itachi and Sasuke talking...im ready for Sasuke to get killed off lol