That has never been an inalienable right. In the context of US law, there is no right to secession of land, only the right to leave the country.
OT: Natural rights include life, liberty, and property, yet gay people only just got the right to marry in all 50 states. We can go through many facets of society where the rights of an individual are inalienated because of their race, sexual preference, or gender make-up. Funnily enough, it's not the federal government that are trampling these rights, it's businesses and other institutions. Somehow they take precedence over the inalienable rights of people, because somewhere along the line, someone co-opted those rights to pretain to anything that doesn't include the government.
So whenever I hear a libertarian or Conservative complaining about how businesses can't discriminate, I call bullshit.
also gr8 point by Frankenstein about Citizens United.