The Uzumaki and Senju. Why is that ?
1. Only 5 People would fight against two clans
Shisui, Madara, Itachi, Sasuke aaand Izuna.
2. Hashirama and Tobirama are sick.
3. Uzumakies has insane chakra reserves and knows the most sealing techs lol.
4. Even if Madara has Rinnegan HE IS NOT ABLE TO SOLO 2 CLANS!
At any point 5vs 2 clans fould be tough fight

Alot would die cause of 5 susanoos and amaterasu spams, plus Paths and Meteors and shit.. But yea they would run out of chakra to deffend themselves and attack so many shinobies lol..
And the Hyuuga well.. There was Neju, His father, Hinata and Current leader of Hyuuga ( Forgot his name ) who would figth aswell.. And they use Taijutsu the most which wood can easily caunter not to mention Edo tensei, S/T and tsunamies in the desert..