Uchihas are the most unique clan.

[Fodder#4]

Ehh. . . I've want Kamui.

 

[Darth Vader]

I would like to say Susano'o, because then Tsukuyomi and Amaterasu are also mine due to the Susano'o requirement. But, I have to say Kamui to be honest. Nothing really beats it.

 

[Jinchuriki Brawler]

I would have tsukiyomi for sure

 

[Under the Rain]

Tsukoyomi or Kamui





But I'd say the Senju were probably the most unique....

Hashirama: Mokuton

Tsunade: Extreme healing and strength

Tobirama: Suiton and FTG Slash

One was also mentioned to be a genjutsu specialist

But you don't to be senju to have these abilities..

I'd choose kamui of course!