Well this is there major weakness, they rely alot on the sharingan.
So if their sharingan gets countered they run into a wall. Ie hasihrama etc..
They need their sharingan or they arent able to compete, lets be honest here.
U can name many shinobi without bloodline limits that hold there own very well.
shinobi like,
3rd raikage, 3rd hokage, minato, etc....
I mean the uchiha showed how desperate they were when they used techs like izanagi and izanami. Look at onnakio and muu they relay alot on his dust techs, but is nice about them if plan A fails there's plan b. Onnaki rock jutsu are epic for example.
Its how it is dudes. Some people are one trick ponies, others arent and are well arounded as a result.
look at the senju, hailed as the masters of all form of ninjutsu, and they were top dog. I think the uchiha's relance on their eyes put them in a disadvantage.
I mean look how hard it is on the clan to get MS and EMS, MS requires some extreme stress like if comrades die etc.. and ems is needed when u take ur sibilings MS. U cant expect to stay top dog for long if u need to these extremes. Its puts alot of stress on the uchiha clan numbers, also not to mention izanagi and izanamo takes ur eyes aswell.
Intresting enough the stronger the uchiha try to become the worse off they are.