Hate it how Uchiha fanboys tip the scale to their advantage. Sasuke can't have EMS if he is fighting along with Itachi (no one ever said edo Itachi) so they both Have MS.
Anyway every MS jutsu requires a big amount of chakra, and also you have to take into account the pain you suffer.
With Naruto's speed they will have to keep Susanoo up all the time (even if not in complete form) therefore using up chakra constantly just for defense.
Naruto is fast enough to avoid Amaterasu and Tsukuiomi... And Sasuke isn't even all that good with Tsukuiomi to begin with.
I highly doubt Itachi's totsuka blade can seal the Jynk (Mintao said that it is physically impossible to seal Kurama with the death ripper seal, and also he said that a Jynk can't use it... therefore a Jynk/Bijuu can't be sealed forever) and even if it could, he would need a very smart plan to catch Naruto.
In my opinion the Uchiha Brothers would loose, especially because of their chakra levels.