Tsunade will most likely die.

[-immortal-]

May the words of this Holly member Rise towards God and may God Feel your pain and let our dreams come true

 

[SIR HERDERP PRESIDERP SDO]

Sasuke ain't killing anyone, it's already confirmed he failed to kill Gaara anyway.

 

[MAN OF SIN]

If Kishimoto isn't willing to let Madara kill her at a perfectly sensible time, he's not going to let Sasuke kill her after a retconned plot twist.

Tsunade doesn't need to be dead for Kakashi to become Hokage. She can live and just give the title to him. Also, if Tsunade dies, that would mean Sasuke succeeds and becomes a dictator...hence no Hatake for Hokage.

She's living btw. All the kages are. We see Gaara alive & Naruto/Sakura happy in "The Last" sketches by Kishimoto.

Sasuke being evil was obvious, dude.

 

[Yami no Kagutsuchi]

If Sasuke wants she will

 

[xxSAGExx]

Sasuke will kill her so Kakashi can be the hokage.

Watch Tsunade not die from Sasuke but die from over using her Yin seal haha it's already said her life shortens whenever she use her Yin seal healing to make her cells reproduce since they can only do that so many times. Shizune said that in part 1 when Tsunade used it after Orochimaru sliced her up. Jiraiya said the same thing about Naruto with going tail modes but Naruto was 16 while Tsunade was 50 in part 1. They both have the longevity of the Uzumaki but Tsunade is 53-54 and been spamming her Yin seal healing.

That or die while reviving someone. Sasuke kills Sakura causing Naruto to go ape s**t on Sasuke and Tsunade revived her.