Previous thread was closed, and I couldn't give my reply to it, so I thought I'd continue the thread, but please with no foul language! 
So, I think that Tsunade would beat Neji low difficulty. How do I know? Well, because, first- Naruto beat Neji in the Chuunin exams, right? And then, AFTER the Chuunin exams, Tsunade beat Naruto with ONE!! finger. And after the Chuunin exams, Naruto was much stronger than before.
So, don't underestimate a Legendary Sannin. She may look weak, because we haven't seen her in a proper all-out battle before, but she is one of the strongest characters in the manga!
So, I think that Tsunade would beat Neji low difficulty. How do I know? Well, because, first- Naruto beat Neji in the Chuunin exams, right? And then, AFTER the Chuunin exams, Tsunade beat Naruto with ONE!! finger. And after the Chuunin exams, Naruto was much stronger than before.
So, don't underestimate a Legendary Sannin. She may look weak, because we haven't seen her in a proper all-out battle before, but she is one of the strongest characters in the manga!