Scenario 1: Mid diff for Hebi sasuke prolly, by what we've seen, his speed is well over tsunades and in a short ranged fight, Chidori Katana and Nagashi should be able to paralyze her, thats not to say a punch from tsunade in byakogou doesnt kill sasuke or that he has a better chance at taijutsu, but manda and continous chidori spam can keep a taijutsu fight at bay. If he gets the weather up for kirin, which requires a lot of Katon spam, then its an unavoidable one shot, if it blew up a Lvl 2 susanoo.
Scenario 2: Taijutsu WILL screw sasuke now, since manda cannot act as a shield/distraction, and i highly doubt sasuke can keep up with a continously regenerating tsunade that can kill him with a fist. Of course if i get into fanboy mode: Chidori Blitz gg.