Tsunade stated that she can't die in a fight

[Horus]

But what happens when her technique runs out?

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and even if its on how is her cellular regeneration going to reach when her head and body are separated? katsuyu cant help cuz she cant summon her

The technique running out is not the point,
She will probably regenerate a head!
Look you're arguing with Kishimoto's words here

 

[Micho22]

If tsunade says so than it is so
Otherwise the fifth hokage woud be a liar

 

[Kusanagi35]

Why is my thread still going on?

 

[Satsujinki]

Why is my thread still going on?

For the lulz, it seems.

What if somebody splits her ass in half with a tree trunk?

She'll come back and ask for more, I guess.

 

[USSJ Future Trunks]

madara thinks otherwise