Doesn't that increase her strength, making it even more deadly? That punch went straight through Orochimaru's jaw, yeah he was phased for a couple seconds, but got right back up. She barely damaged his facial mask. Not even mentioning how Naruto sent him flying with a Kyuubi chakra enhanced punch, yet he came back out giggling.Tsunade's strength was greatly weakened after Kabuto severed her muscles, to the point she couldn't even put down a paralysed and immobilised Kabuto with few hits. She needed to use Sozo saisei to compensate with the obvious lack of strength's state she was in since that moment. Still that hit was enough to put Orochimaru down and force him to retaliate
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