Tobirama's death

[Itachi of Akatsuki]

Due to hype, Tobirama presumably died fighting; Ginkaku, Kinkaku & 20 elite jounin which could have been Asuma level or a bit below. He survived for at least 20 mins to let his group escape in time, apart from Hashirama would there be any Hokage capable of doing that? Keep in mind Kakuzu could possibly have been present at the time.

Manga feats - Minato & Hashirama would be capable of surviving/winning the fight

But could Hiruzen or Tsunade do that?

 

[Gin-San]

I don't know about Hiruzen, but Tsunade is able to by healing hax.

 

[Uzeless]

Hiruzen could not even beat down Orochimaru, how could he defeat them. Tsunade wasn't a match for Pain, how could she withstand them?

 

[BryanSk8]

Hiruzen was shown to hold his own against orochi, at least 10 mins of holding out. Maybe more if with Anbus.

Tsunade would be basically a fodder since against fodders she can flick them like nothing, and with reg's she can barely punch them lol.

 

[LordSasukeOfSixPaths]

hiruzen and tsunade wouldn't have lasted and both hashirama and minato would have took them out