The Sharingan is gone for good with Sasuke's death

[LeSauce]

Even if Sasuke's children were full bloods, they would still have a small chance of getting th Sharingan, so you're probably right.

His daughter still has Uchiha genes though, and there's still a slight chance she'll awaken it, however small.

 

[SBDaBomb]

Sasuke could just transplant his eyes into his daughter before he dies...?

 

[lndra]

Actually you are incorrect. Let me explain ... Sasuke's daughter has the Sharingan gene because it is dominant on the father's side, Naruto's kid did not obtain the Byakugan gene because of Naruto. Most likely they both have large chakra pools but it is still uncertain if the children can activate the Byakugan or not, they may have it but still have the father's eyes. We've never seen a Hyuuga mate with another popular clan before. What is proven: -Sasuke's daughter has the Sharingan gene. Whether she activates it or not, is up to Kishimoto. I mean it's a time of peace.. -Naruto's kids are hack. I mean either one of them can become another Naruto, Hinata (Hyuuga), Minato (Naruto's son is named Buroto which means Bolt, so FTG?), and/or Kushina. You have to remember the genes of the father/mother (ancestors) are still active within the body. Anything can happen.

 

[Swagdara Uchiha]

She will never awaken it though. With Sakura and Sasuke I doubt that kid has to worry about any life threatening scenarios.

 

[Zee U]

Since Sasuke is a full blodied Uchiha and Sakura doesn't have "special" genes (unlike Naruto that has Uzumaki genes and Namikaze genes), it's way more probable his kids will have Sharingan.