The most talented shinobi from the series?

[Amazeballs]

The fact that the Mokuton can be implanted through Hashi DNA proves that it is not a learned technique.

 

[Lasta]

does hiruzen qualify, if he does then my pick will be
1. Hiruzen and Tobirama
2. Minato
3. Gai and Lee
oh and maybe Kisame

 

[loj]

Minato.

 

[KesOnFire]

Tobirama
Minato
Oro
Hashirama
Kakashi

 

[Reboryushon]

Prime Hiruzen.

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[Tobi obito]

3rd Hokage!!

 

[Itachi Edo]

Honestly, I think it's Minato and Sarutobi is a very close second.