Black Zetsu (aka rapist) one-shooting Madara with the Juubi, Rinnegan and Rinne Sharingan. Only Kakashi getting double Mangekyō Sharingan can rival that cancer.
Sakura - She just irrelevant that why.
Minato - This person is a jerk to Naruto, Kushina and Team Minato he should alive no need to be die because of plot.
Itachi - Easily brainwashed by Danzo to kill his family, friend and relatives.
Obito - Rin nonsense> Entire human beings