Ashura and his descendants were also prone to the 'curse of hatred' like the Uchiha
But the reason BZ failed with Senju is because the hatred that Uchiha experienced came from the strength of their chakra which in turn affected their mental energy.
In Senju and Uzumaki's case the only way their chakra could influence their mind in the same manner would be as a jinchuuriki. Kurama's chakra corrupted Naruto's mental state which led to numerous rages comparable to Taka Sasuke.
The bijuu and dojutsu are both catalysts that allow Kaguya's will to manifest in the users because they contain a direct piece of her chakra. Physical and mental energies are what chakra constitutes of, meaning if you have bijuu chakra or Sharingan chakra then you also possess a direct piece of her mental and/or physical energy.
Indra inheriting Sharingan was a genetic factor which would mean so are the side effects of the dojutsu. His descendants and him were all prone to mental instability like Kaguya because the Sharingan's chakra was originally part of the power that enthralled the Sage's mother.
The Uchiha's genetic condition made it seem like they were cursed because it's been passed down since Hagoromo's birth with no explanation as to why (until BZ betrayal). In reality it's not a curse and just a condition that can be treated naturally with ninshu and some Hashirama Kush...
I personally think BZ could've succeeded with Senju but only had he focused on giving them hateful bijuu like Kurama and Son Goku. But the rate of success would still be nowhere near the Uchiha because the forrest dwellers retained Hagoromo's values and lacked the same level of Yin that dojutsu users wield.
Through Ashura's teachings and by not having bijuu chakra as their natural power, the Senju avoided the corruption of the mind that occurs when one possesses a piece of Kaguya's power. You could argue that Ashura's lack of chakra genes made his descendants stronger.
P.S : Sorry for repeated use of words like "chakra" and "mental energy", I'm trying to avoid terms like 'Yin' and 'Yang'
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But the reason BZ failed with Senju is because the hatred that Uchiha experienced came from the strength of their chakra which in turn affected their mental energy.
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In Senju and Uzumaki's case the only way their chakra could influence their mind in the same manner would be as a jinchuuriki. Kurama's chakra corrupted Naruto's mental state which led to numerous rages comparable to Taka Sasuke.
You must be registered for see images
The bijuu and dojutsu are both catalysts that allow Kaguya's will to manifest in the users because they contain a direct piece of her chakra. Physical and mental energies are what chakra constitutes of, meaning if you have bijuu chakra or Sharingan chakra then you also possess a direct piece of her mental and/or physical energy.
You must be registered for see images
Indra inheriting Sharingan was a genetic factor which would mean so are the side effects of the dojutsu. His descendants and him were all prone to mental instability like Kaguya because the Sharingan's chakra was originally part of the power that enthralled the Sage's mother.
The Uchiha's genetic condition made it seem like they were cursed because it's been passed down since Hagoromo's birth with no explanation as to why (until BZ betrayal). In reality it's not a curse and just a condition that can be treated naturally with ninshu and some Hashirama Kush...
I personally think BZ could've succeeded with Senju but only had he focused on giving them hateful bijuu like Kurama and Son Goku. But the rate of success would still be nowhere near the Uchiha because the forrest dwellers retained Hagoromo's values and lacked the same level of Yin that dojutsu users wield.
Through Ashura's teachings and by not having bijuu chakra as their natural power, the Senju avoided the corruption of the mind that occurs when one possesses a piece of Kaguya's power. You could argue that Ashura's lack of chakra genes made his descendants stronger.

P.S : Sorry for repeated use of words like "chakra" and "mental energy", I'm trying to avoid terms like 'Yin' and 'Yang'