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We all know that Madara was rocking that Scythe back in the day. He was slashing up hashirama up pretty good! Thanks to Hashirama's godly healing power, he never drop dead. But there is a limit to how many time the body can regenerate itself.
A body's cells can only split a certain number of times in a lifetime, and by speeding up this process, users of this technique are basically shortening their natural lifespan. This is hayflick limit. So Hashirama probably gotten weaker in old age and finally turned into a damn tree.
I wouldn't be surprise about Karin uzumaki being the same way. All that bite marks on her.
A body's cells can only split a certain number of times in a lifetime, and by speeding up this process, users of this technique are basically shortening their natural lifespan. This is hayflick limit. So Hashirama probably gotten weaker in old age and finally turned into a damn tree.
I wouldn't be surprise about Karin uzumaki being the same way. All that bite marks on her.
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