mei was about to use a jutsu while tsunade used herself as a shield so there is no proof that tsunade is faster.Hands aren't feet kid. Orochimaru could defend himself clearly he attacked multiple times. I love how that's all you could answer with.
Madara played? Where's your proof, she still reacted to katon faster than Mei could have hoped to so we know she's faster than her and she's the only kage to have fought by herself, gaara was saving meis butt on several occasions. I'm not giving her feats the manga is.
So many wrong things in your post, you tsunade fans are just.... no :|