I've tried that before but I didn't like it much. It uses too much resources and gives the "soap opera" effect which makes the video look weird to me.
If you want the best experience watching movies/Anime I reccomend using the following:
1)
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. (x86 because MadVR isn't 64-bit)
2)
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video renderer.
3)
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for decoding. (You can skip this if you're using the integrated one in MPC-HC)
4)
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for AV syncing.
MadVR gives the best picture quality you can ask for but you need to learn a bit about its scaling algorithms.
Also, make sure you switch your display to the correct refresh rate.