A lot of people are having a great misconception on how the 2nd mizukage's yin element works.
Genjustu is when you are trapped inside an illusion inside of your mind.
The only way to stop it is by disruption of the chakra.
The mizukage's yin release genjustu, is a genjustu/illusion that is being projected in the real physical world.
Distrupting your chakra will not accomplish anything considering that you are not in the illusion, but the illusion is confronting you in the real world.
Since it's spiritual energy you can't touch it, but it can touch you.
If the illusion and the real body fights Orochimaru, how would he win?
I think it can go either way considering that Orochimaru is a genius and immortal