i think that sasuke is going to end up dieing at the end of shippuden due to over use of susano
unless EMS allows you to do it with out damaging you in some way.
we can't know for sure if orochimarus done for hes a devious dude and theres a lot of his chakra still floating around, at topic sasuke even though hes a douche deserves a better death than that and I feel that the only way he can die is fighting naruto
i dont believe sasuke going to die at all who will carry on the uchiha legacy not madara itachi is dead sasuke will probably be naruto villian friend until the whole saga is done. i truly believe that he's going to find out that madara lied then he will wanna take his life naruto is going to stop him he will then reform the uchiha name for the sake of itachi he will remain an friendto naruto and when naruto ever needs his help he will be there...