Naruto, Haku, Gaara, Kimimaro, Sasuke, and Kakashi all have pretty equal pain of lacking/losing bonds. I personally think Naruto, Gaara, Bee and the jinchuriki suffered the most because it's hard enough never meeting your parents or being rejected by them, let alone having an entire village ridicule you to the point of turning you into a killer. A monster shoved inside you and THAT becomes your psyche, a venomous beast that infects your universe and causes everyone to view you like a virus that needs eradicated.
"It's better to have loved and lost than never to have loved at all" kind of thing. At least Sasuke experienced family love for a short while and had an older brother forever watching his back. Naruto had nothing, and had his only real familial bond in Jiraiya ripped away and he handled it like a champ.