^^^ This. Your question has been answered.Only if if hit his heart directly
With his jutsu... A Hyuuga could only dream of getting close to Sasori.Only if he gets hit in the heart. But I doubt he would just stand there and wait to be hit.
This basicallyI know it is a mechanical indestructible body, but he still uses chakra and that has to come from somewhere so would attacks like the gentle fist be effective on him.