Sasuke, mid/high difficulty. Sakura was arguably able to dodge Sasori's IS attacks by the end of her fight [
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], and her speed wasn't what you'd call special. Sasuke was in another league in the speed department at the beginning of Part 2, so he shouldn't have trouble dodging. Sasori's 100 puppets aren't really an issue - again, Sakura was able to fight [
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] and dodge [
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] them without getting hit, let alone Sasuke, who defeated hundreds without even aiming to kill [
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], not to mention he could just use Chidori Nagashi if needed. Manda can also be genjutsu'd and serve as a quick assault from underground, or as a defense from the needles, which should be more than sufficient, considering a regular snake completely defended Sasuke from an explosion [
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][
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]. Since Sasuke knows of Sasori's style/attacks he wouldn't have to make unnecessary moves and can simply aim to finish him off with a direct hit from Chidori Spear to Sasori's core, which he'll undoubtedly figure out as soon as Sasori's Akatsuki cloak gets removed. This is all without even taking CS2 into account, so I really don't think Sasuke will lose this one.