Is this some sort of joke? Lee can't do anything to either of them, and Neji's attacks are close range, which sort of spells death against Tsunade, especially considering that his gentle fist wouldn't be able to kill her.
I will explain my last sentence. Gentle fist works by putting chakra at the tips of your fingers to hit the chakra points in the chakra circulatory system. Kabuto in part 1 uses chakra scalpels on his hands to attempt the same thing on Tsunade, but fails. His reasoning is, and I quote, "Was it because her fat breasts were in the way?"
Either way, it apparently was ineffective because of said "fat breasts". So my conclusion is that gentle fist wouldn't be able to kill Tsunade, but only stop her chakra in places like her legs, etc. but while Neji is doing that he is quite open to an attack from Tsunade, which would spell his doom.