I think Kishi's been hinting for awhile that there will be major character deaths. He's shown us he is willing to kill main characters and K11 members. Who bites the dust? Kakashi is needed for plot. Hinata is needed as a value to Neji's sacrifice. Sasuke and Naruto are probably not on the chopping block.
The remaining option is Sakura. Nobody really likes her character except moron shippers. So how will she die, Madara, Juubi... Sasuke?
The remaining option is Sakura. Nobody really likes her character except moron shippers. So how will she die, Madara, Juubi... Sasuke?