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I think Gudoudama is doing serious damage on pure ninjutsu body(edo) and not body flesh with ninjutsu(alive human).
Pretty Much. Sakura's regeneration is using chakra to rapidly increase cell reproduction, rather than create an entirely new body part from chakra. Gudou Dama's nullify the new arm because it uses pure chakra, but Byakugou just uses Chakra to increase growth.