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1. Okay, I admit this is a good point. But still, Tsunade was using this technique for years, is much older than Sakura and she is still fine. Normal cells are limitied to 70-80 times division before they die. Sakura is still young, therefore I don't think Sasori can force her to overuse the seal and die.
2. And this is why I said the battle is debatable. Kakuzu's elemental attacks are pretty strong, especially his raiton.
3. Well okay.
1. The poison keeps spreading at an extreme rate. The cells will be dying at the same time new one's are being made, both of these processes are rapid. Eventually Sakura will either pass out or be immobilised by the fast spreading poison. Shizune wouldn't have been worried about it if it wasn't achievable in a normal fight. A normal fight where poison wasn't used, to be exact. Poison being utilised, however, is a far worse situation, thus I have no reason to believe Sakura will remain unaffected. Sakura won't be in a top form even while her cells are splitting since she is still majorly poisoned. The new cells are dying and the old cells are dead, she isn't in a good form. Unless you have an actual argument against this point I brought up, the poison remains uncountered.