It could go either way.
In a CQC, Lee rapes Sasuke but CM2's Durability is a factor. People think because he has 3T, he'll automatically react to every single one of Lee's moves because he reacted to KN0 Naruto's attack. No limit fallacy. It gets to a point where it won't be able to read some movements and won't even be able to react even if it can. Then again, CM2 doesn't put him on Lee's level in terms of speed and reactions at all. He resorted to Chidori because he couldn't last long in CM2 when he felt some pain and noted he didn't have time
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so he's not going to outlast Lee.