Hashirama stopped Madara on his own already, and even with the wood release and Rinnegan, he doesn't have the Kyuubi, which Hashirama also overpowered. I think Kyuubi trumps Rinnegan and wood release, meaning that Hashirama could still beat him. Also, to say that Hashirama wouldn't defeat his own techniques would be silly. I think Tsunade could take Sasuke by herself, and if not, she and Tobirama together could. Hiruzen in his prime plus Minato could give Itachi a run for his money...I think the five Hokages.