Pein vs Kisame and Itachi

[Kage of the Hood]

Itachi wins low diff.
kisame watches from sidelines and enjoys the show

that's why nobody takes itachi fans serious... yes if he catches then in genjutsu but it's not that easy....
and this is a question i been having is there any cannon proof of itachi attacking while yata is up? if not that's a susanoo weakness

 

[A$AP Wap]

The Six Paths of Pain wins this.
Itachi is fragile, and Kisame is powerful, but will end up losing.
In the end, Pain laughs at both of them attempting to defeat God.

 

[The Necromancer]

Deva Solo
huge shinra tensei & they both die

With nagato within the city, that would end in a tie or victory for itachi and kisame.