I'll simply end it as I have got no time to write a wall of text now.
Let us say that they'll start with
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, as u already know Orochimaru has advantage with his summonings so one of them should try to deal with Manda where as the other one'll try to attack Orochimaru,since both Tsunage as well as Sakura are close range fighters Orochimaru can use
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,nither Sakura nor Tsunade can escape it as even Enma can't esape it.even if they can,Orochimaru is more than capable of killing Tsunade/Sakura with the
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even b4 they can escape it (Orochimaru know how to kill Tsunade)then he can take care of the other one.
They can't even deal with base Orochimaru let alone
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.