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poisons and virus are usual thrown in small amounts that spread and multiplies even if you give an elephant the same amount as a human it still gets poisoned probably takes longer to take effect but it still happens.
Lady chiyo is much more clever & powerful then you think during the 3rd ninja war she was able to take on hanzo multi times and gave a fight the same man who sweep tsunade,jiariya, & tsnuade at the sametime.
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Hanzo was also fast in speed as proof body flicker
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so if you think chiyo is easy to hit get serious
This is all irrelevant and/or speculation, okay Chiyo fought Hanzo and Hanzo can shunshin, does that mean that Chiyo can keep up with the 4.5's? No, not really, you stated yourself she was a 3.5(or so lol, don't remember the exact statistic) and were trying to downplay her speed to back up the 3rd Kazekage/Sasori's. Well Chiyo still reacted, Orochimaru is a 4.5 so should be able to even easier, Manda is faster than any of them have ever shown and will just snap his jaws down to smash the puppet. Nothing you posted here stops that from happening.