Orochimaru high difficulty.
The biggest threats will be Kakuzu's elemental attacks that has enough power to destroy forests, however, Orochimaru has what it takes to get through that.
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Orochimaru can fight Kakuzu 1 on 1, but his masks will get on the way, so Orochimaru can create Bunshins of himself as Zetsu demonstrated [
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]. Orochimaru through his rebirth Jutsu consumed a biological clone of white Zetsu. Therefore, he has the ability to perform every arsenal of white Zetsu.
As the 5 clones proceeding to fight the masks are Fire, Water, Earth, Lightning and Wind with each of them having the ability to use per nature transformation. Orochimaru needs to first get rid of the Lightning mask, and to do that, he can erase its existence through his Fuuton breakthrough [
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]. The Jutsu has enough strength to penetrate a portion of forest. Fuuton > Raiton.
Orochimaru may not have the nature transformation to take each of them out, however, he can use a roots of Mokuton [
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] [
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] to restrain their movements and start to absorb their chakra rendering them as Mokuton showed the capability to absorb or suppress chakra. Orochimaru has possession of Zetsu's body, meaning he can make use of Mokuton.
As Orochimaru will have trouble breaking Kakuzu's Domu due to the lack of fire-power, however, he can use his sword of Kusunagi that hyped to be cutting an object as hard as diamond [
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], and Kakuzu's Domu was hyped in the Databook to have skin as hard as diamond [
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]. The sword will cut through Kakuzu's armour and kill him.