Orochimaru may have a severe weakness to Hashirama.

[Shroompowah]

Orochimaru's entire body is made from his DNA, and even tho Orochimaru is used to controlling other's bodies.

But given Hashi's insane power level and they were/are his cells, Orochimara might get insta owned. When Hashi learned in the recent chapter of what Orochimaru's body is comprised of it seemed to me he might've realized this.

What say ye?

 

[ImAFish]

his only weakness is a mirror

 

[3MESSIAH]

hashirama wood rapes orochimaru?? i think you are right

 

[Kages]

That's plausible :y

 

[Shroompowah]

Hashi might be able to cause Orochimaru's body to turn into a tree, or just forcefully move it as he does his wood release, maybe he'll force him to perform the edo tensei release jutsu, freeing Hashi from control but leaving him still in the world.

 

[xCrystalChidorix]

Well, it stands to reason that the person who would know the most about the weaknesses and strengths of his own cells and DNA would be Hashi.

So....yeah. It's possible.

 

[NinjutsuSeeker]

hashi is everybodies weakness....

 

[Killer Bee and Samehada]

xdHAHAHAH ur funny, anyway Hashirama doesnt seem that he would take advantage of you, Only maybe if he really has to

 

[Tormound]

If orochimaru is made up of Hashirama's cells, won't that mean Naruto can beat him easily? He can just enter Kyuubi Chakra mode and just stand next to him. Orochimaru would be forever immortal as a tree.

 

[Chibiusa]

Even if he didnt have a weakness, I'm pretty sure Hashirama could insta own Orochimaru anyway

 

[Gaara]

Hashi will own orochimaru.