With Orochimaru knowledge on Hashirama DNA, Senjutsu, curse mark, being able to make living kids like Mitsuki and Shin, making himself younger, etc, that would be useful knowledge towards Amada who knows a lot about the karma, scientific ninja tool, cloning ninja like Kashin Koji, etc.
Imagine Karma with Senjutsu that would be really powerful.
Imagine Karma with Senjutsu that would be really powerful.