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Lagus, first a traitor, now a time machine. A true villain
As for the central knights I have a feeling that somewhere in some past chapter around where they try and stop Regis it is said that they are humans?!? Not sure though.
The split up is always a dumb strategy, especially when against another group. If you split and they don't you get ganked and RIP. Basic MOBA strategy

But I agree, I think it's going to be Bleach-like 1v1 all over the place.
Maybe Lagus vs Rozaria? Could be interesting.
Also the two werewolves against Kaye perhaps and the blonde chick against Ludis?
And Gradeus finds no one until Franken and Rai meet him and he gets destroyed? Yeah that would be nice.