Mu and Onoki win whether Hashirama is hyped or not. Jinton obliterates mokuton and makes healing useless. Flower tree world is easily evaded by flight or destroyed by jinton. Hashirama can't track an invisible Mu allowing him to sneak up to Hashirama while Hashi is fully focussed on Onoki.
Those weighted rock techniques are pretty useful as well for defence and for offence. If Mu manages to tough Hashirama, he becomes very light and then he is knocked to the sky by a heavy weight rock smash.