- Kakuzu is a mid-long range fighter. His attacks are never going to land on Minato. His tentacles are even made for capture. Capturing Minato is impossible
- Minato is faster than him. Whether Kakuzu decides to fight with his masks inside him or not, all Minato has to do is to mark the original body and strike him down
- Kakuzu's gian could be redirected by Minato's S/T barrier to make Kakuzu's doton domu ineffective. Judging by the piercing power of said "Gian"(and the hype given by the databook), it should even pierce through kakuzu completely and thus killing him. Although with other hearts, he should revive himself(if they are inside him, that's it), but he would lose the doton mask
- It also seems that people think the doton domu is Kakuzu's natural skin. No, it's a earth jutsu that Kakuzu needs to activate(it necessite one handseal). Minato's FTG teleportation speed is too fast that Kakuzu won't even have time to activate doton domu in time, so Minato could casually kill him even if he had the doton mask still active because of the impossibility to react in time.
- This is just a bonus, but i'd like to point out that when Kakuzu uses the doton domu, his body is uncapable to move until he deactivate the body, he basically becomes like a statue. He has only shown to be capable to move when he uses the partial version of it(on his arms for example)