Part1 Kabuto has shown he wasn't able to regenerate himself against Rasengan. It would depend if he receives a direct attack or if he has time to turn himself in liquid. But having a marking makes a surprise attack, so he won't probably get time to turn to liquid and get killed then. Contrary to the popular belief, Kabuto isn't untouchable, far from that. He uses a jutsu, if he doesn't get the time to use it, he is vulnerable. If Minato really feels the need, he can seal him anytime. It won't be easy, but he sure can. Even with Edo's it won't really change the outcome from the moment Minato would stop it with a contract seal