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Tsunade's regen comes from a seal, not conscious chakra flow.
That's cool. Assume she can regenerate the bone. Her neck bones will still look like this.
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When bone is broken and regenerates it needs to be snapped back in place - hence why you go to the doctor to fix it and don't simply wait for it to heal - which Byakugou can't do. Byakugou will produce new cells but these cells are not smart enough to fix themselves properly.
Byakugou is natural regeneration amplified 1000 times. It will not make organs grow back properly if they were damaged.
I also doubt that he could snap her neck just like that. I mean, we've never seen someone's neck being snapped by a blow even if that person's much stronger than the other.
Tobi did it easily.
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