well i was not trying to convince you, just expressing my point of view here.
the thing is, we still don't know what tsunade has in her sleeve as we've seen she has a new technique now and we don't know if she learned Sakura those techniques as well.
So we must be balanced here. As well not forget that for an amount of time, Tsunade is invincible and the girls need to take care of that...
But who knows.
Anyway, it is a very nice idea to debate on
Sakura can't hold Tsunade off in no way.
Hinata is weak in Taijutsu, she wouldn't prove to be anymore trouble than Sakura.
Tsunade is said to be unsurpassed in Taijutsu, that means Hinata and Sakura are dead.
Ten Ten won't be a problem either, Tsunade as a medic has to be agile and evasive, she would dodge the weapons and close the distance. If Sakura can evade Sasoris weapons than I'm sure Tsunade can evade Ten Tens weapons.
Ino is fodder in this fight, she wont be able to lock on to Tsunade with that weak jutsu. Even if she did manage to catch Tsunade, Tsunade used her medical Ninjutsu to reverse the damaging effects of Tsukuyomi so I'm sure she could counter ino's mind transfer attack.
The Slug has the ability to split into enough slugs for each person in the leaf village each of those slugs on the ground all shooting their acid at them would leave them open for Body derange jutsu which isnt hard to get off on a group of people because she can just run and chop to do the tech. Tsuande using her Rebirth jutsu makes her capable of running through the acid and with them left like that they would be easy picking. The slug summon is very useful btw Tsuande is not slow people picture her as this because she very strong and because they always compare her to A she has about the speed of a average ninja. Her shock waves from her attacks breaks buildings which prove even if she misses its devasting to be hit by the shockwave. Just being close to the attack could nearly kill you.
The major problem I see that stops the girls dead in their tracks in Katsuyu. There's really nothing you can do about her unless Ino tries to mind-transfer her. But then Tsunade could smash her body.
According the the databook Tsunade's strength is atleast (it's capped at 5) two tiers above Sakura (and according to the Wiki Tsunade's natural strength is far greater than Sakura's enhanced strength), and her taijutsu skills are atleast two tiers above Sakura, her stamina is one and a half tiers better, but in terms of stamina feats Tsunade has the most of the people here. Tsunade is at least a tier above Sakura in intellect. Tsunade is a tier faster, and Tsunade's ninjutsus is atleast two tiers above Sakuras.
Hinata's taijutsu is atleast a tier and a half behind Tsunade, her intelligence is atleast a tier and a half behind Tsunade's her speed is a tier and a half lower than Tsunade's. Her Stamina is two tiers lower than Tsunade.
Ino's ninjutsu is atleast a tier and half behind Tsunade, her taijutsu is atleast 3 and half tiers below Tsunade, her genjutu is half a tier below Tsunade, her intelligence is atleast 2 tiers below Tsunade, her strength (seriously?) is two tiers and a half below Tsunade's, her stamina is a tier and a half below Tsunade's and her hand seal speed is a tier and a half below Tsunade's.
Statistically Tenten is the furthest from Tsunade. She throws stuff. But well we've only ever seen one person try to throw things at Tsunade.
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I argue Tsunade will be doing something of that nature. Bearing in mind that Hinata and Sakura are both close range fighters Tenten would have to take extra careful aim to hit the dodging Tsunade without hitting the attacking girls. My point being just going against Tsunade the girls have their hands full. They might even be able to pull out a win. But when Tsunade summons Katsuyu. All hope leaves the battlefield. Tsunade's hand seals are fast enough to pull this off
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We don't even see the hand movements being made. So summoning jutsu which requires 5 hand seals should be too much of a problem to pull off. Ino's mind-transfer technique may not prevail against Tsunade, we know that it can be overcome by will-power and we haven't really seen Ino try to control someone with a strong will power since part 1 Sakura. So I say the girls lose. Mid difficulty after Katsuyu shows up.