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He put so much thought into stuff like this. The hayflick limit? What other anime incorporates such specific real life biology into their explanations of techniques? Never knew about this, makes immortality seem like even more of a stretch, basically every time our DNA is replicated to make a new cell the proteins involved cannot duplicate the entire chromosome so it gets shortened. Eventually chromosomes lose too much information and you can no longer produce functional cells. That's why Tsunade's technique shortens her life span because it makes the proteins hasten cell division to heal wounds but in the process hastens cell death.
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