it could be foreshadowing something happening to Sakura as a result of Tobi being bitter over the fact he lost Rin. He could take Sakura (or Hinata, whoever Naruto likes...based on the manga id say Sakura is the likely candidate) away from Naruto to gain the upper hand. I think the fact that Obito turned over (to our knowledge) something like losing the person he was in love with, Naruto has had hardships but nothing quite like that.
As far as other foreshadowing goes, i actually dont think Sasuke is going to try and hurt Naruto and Sakura this time. I could certainly be wrong, but since hes had his little talk time with Itachi, Sasuke hasnt been quite as emo as usual. I think its possible Sakura could (like the first time) jump in between Sasuke and Naruto to protect Naruto or both from hurting each other (i see the first happening because Sakura doesnt respect Sasuke like she used too) but id be seriously pissed for one if Kishi did that...and so would Naruto and alot of Japan and it just wouldnt make since to kill her off (especially when she should have died many times before now lol)